Comparison of Pathological Features of Prostate Cancer in Cohort ...

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Cancer Research

[Abstract]

Incidence of prostate cancer is increasing steadily inChinese and Japanese because of screening with serumPSA. Both China and Japan are Asian countries andpopulations in the two countries are yellow race. Thelatitude of Changchun is close to that of Natori. Thedetection rates of prostate cancer are different in cohortin two areas. It is unknown whether pathological featuresdetected prostate cancer are different in the two areas.At present, there is no report of pathological features ofprostate cancer in cohort in different areas of the twocountries. To study this issue, we analyzed andcompared pathological features of prostate cancer incohort though the screening data of and Jilin UniversityProstate Diseases Prevention and Treatment ResearchCenter (Changchun) and Miyagi Cancer Center (Natori).For 5 years (2000 to 2004) in Changchun, China andfor 10 years (1995 to 2004) in Natori ,Japan, 15192Chinese and 4444 Japanese men aged 50 and over werechecked by PSA-based screening. All men with theserum PSA value greater than 4.0ng/ml wererecommended for a prostate biopsy. All histopathologicdiagnoses of the biopsied specimens were confirmed bya group of pathologists in two areas. The pathologicalfeatures of prostate cancer of Chinese were comparedwith those of Japanese, including Gleason score, extentof differentiation , invasion, histological pattern and soon. Statistical analysis was done with the aid of statisticsoftware SPSS 13.0.The results of our research is follow:(1)The cancer detection rate for the PSA-screenedmen in cohort was 0.7%(102/15192) in Changchun and2.6% ( 117/4444 ) in Natori. The differences werestatistically significant(P

Title: Comparison of Pathological Features of Prostate Cancer in Cohort Through Mass Screening in Changchun, China and Natori, Japan

Category: Cervix Cancer

Filename: Comparison of Pathological Features of Prostate Cancer in Cohort Through Mass Screening in Changchun, China and Natori, Japan.pdf

Pages: 128

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